Immune function disorders
This Editorial Guide is used for Education Purposes Only. It is used in the Authoring Courses and Certifications. It is based on the January 2026 Editorial Guide.
Hypersensitivity
473010000 |Hypersensitivity condition (finding)| is a primitive concept. It subsumes 473011001 |Allergic condition (finding)| and 609405001 |Non-allergic hypersensitivity condition (finding)|.
473010000 |Hypersensitivity condition (finding)| is a direct descendant of 404684003 |Clinical finding (finding)|.
473011001 |Allergic condition (finding)| and 609405001 |Non-allergic hypersensitivity condition (finding)| are both primitive concepts. Each has three main subhierarchies representing:
Diseases/disorders: abnormal structures
Processes: allergic and nonallergic hypersensitivity (pseudoallergic) reactions
Dispositions: propensities to develop allergic and nonallergic hypersensitivity (pseudoallergic) reactions; they do not have pathophysiologic manifestations prior to allergic and nonallergic hypersensitivity (pseudoallergic) processes, i.e. reactions
Diseases/disorders and reactions, but not dispositions, are defined by underlying pathological processes.
Pathological process (qualifier value) hierarchy
In order to fully describe the full range of hypersensitivity responses, there are qualifier values in the Pathological process (qualifier value) hierarchy. (See also Qualifier Value page).
Allergic reaction
Allergic reaction (disorder) has a Causative agent (attribute) of Substance (substance) or its subtypes. This attribute-value pair is grouped with another attribute-value pair of Pathological process (attribute) and Allergic process (qualifier value).
Allergic process (qualifier value) is a subtype of Abnormal immune process (qualifier value) which means allergic disorders, as well as autoimmune disorders, classify as types of disorders of immune function. Disorder of immune function (disorder) modeling with Abnormal immune process (qualifier value) allows allergic and autoimmune disorders to correctly classify as subtypes of Disorder of immune function (disorder).
Allergic and nonallergic hypersensitivity (pseudoallergic) disease
Allergic and nonallergic hypersensitivity (pseudoallergic) diseases represent manifestations of pathologic processes that result in abnormal structures. Modeling an allergic and nonallergic hypersensitivity (pseudoallergic) disease includes the following relationship group:
IS A: Disease (disorder)
Associated morphology (attribute): subtype of Morphologically abnormal structure (morphologic abnormality) representing the abnormal structure
Finding site (attribute): subtype of Anatomical or acquired body structure (body structure) representing the abnormal structure
Pathological process: Hypersensitivity process (qualifier value) or one of its descendants
Causative agent (attribute): Substance (substance) or one of its descendants, if known
For example,
Allergic and nonallergic hypersensitivity (pseudoallergic) disposition
Allergic and nonallergic hypersensitivity (pseudoallergic) dispositions are propensities to develop allergic and nonallergic hypersensitivity (pseudoallergic) reactions; they do not have pathophysiologic manifestations prior to reactions. They are considered clinical findings, not disorders. This further distinguishes them from allergic and nonallergic hypersensitivity (pseudoallergic) reactions.
Allergy to X (finding) will have the following modeling:
IS A: Propensity to adverse reaction (finding)
Role group of:
Has realization (attribute): Allergic process (qualifier value)
Causative agent (attribute): subtype of Substance (substance)
For example,
For example,
Nonallergic hypersensitivity (pseudoallergic) reaction
Nonallergic hypersensitivity (pseudoallergic) reactions are adverse reactions; they are defined by an underlying pathological process.
For example,
Figure: Example of nonallergic hypersensitivity (pseudoallergic) reaction model in stated view
Intolerance to substance
An intolerance is the propensity to develop an adverse reaction to a substance. The adverse reaction may be associated with various pathological processes, but specifically excludes hypersensitivity reactions.
It may be difficult to define the pathological process and to associate the substance with the propensity to develop a reaction. Consequently, 47429007 |Associated with (attribute)| is used to model intolerance to substances.
For example,
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