Substances specifying intact, fragment or subunit

This Editorial Guide is used for Education Purposes Only. It is used in the Authoring Courses and Certifications. It is based on the January 2026 Editorial Guide.

Overview

Fragments are created as siblings of the intact/whole/entire substance.

“Intact” should not be included when referring to the "entire substance" or "whole substance"; it is implied.

Alpha and beta sub-units should be the children of the entire substance, where "nicked" substances and fragments should be the siblings.

INN should be used for the Preferred Term where they exist.

Modeling

Parent concept	Most distal appropriate descendant of 115668003 |Biological substance (substance)|
Semantic tag	(substance)
Definition status	Primitive
Attribute	|Has disposition| as appropriate

Naming

FSN

Pattern:

• X fragment (substance)

• X subunit (substance)

For example,

• Corticotropin, big fragment (substance)|

• Thyrotropin beta subunit (substance)

---

Preferred Term

Pattern:

• X fragment

For example,

• Corticotropin, big fragment

• Thyrotropin beta subunit

Provide Feedback