# Substance Groupers Based on Disposition

<mark style="color:$danger;">**This Editorial Guide is used for Education Purposes Only. It is used in the Authoring Courses and Certifications. It is based on the January 2026 Editorial Guide.**</mark>

## Overview

Groupers based on disposition that are deemed to be clinically useful and that can be sufficiently defined will be included in the |Substance| hierarchy. Disposition is defined as a behavior that a substance will exhibit or participate in, given the appropriate context. There is no requirement to introduce a new semantic tag in order to distinguish concepts representing a substance disposition from any other type of concept in the |Substance| hierarchy.

*Note: This section applies to concepts representing a single disposition. It does not apply to concepts representing a disposition combined with a structural grouper or concepts representing more than one disposition.*

## Modeling

<table data-header-hidden><thead><tr><th width="176.88671875">Parent concept</th><th>105590001 |Substance (substance)|</th></tr></thead><tbody><tr><td><strong>Parent concept</strong></td><td>105590001 |Substance (substance)|</td></tr><tr><td><strong>Definition status</strong></td><td>Defined</td></tr><tr><td><strong>|Has disposition|</strong></td><td><p>Range: &#x3C;726711005 |Disposition (disposition)</p><ul><li>While the allowed range is broader, the Substance Groupers based on Disposition should only use &#x3C;726711005 |Disposition (disposition) as the attribute value.</li></ul><p>Cardinality: 1..1</p><ul><li>While the allowed range is broader, the Substance Groupers based on Disposition should have one and only one |Has disposition| attribute.</li></ul></td></tr></tbody></table>

Substance groupers representing etiopathic dispositions (e.g. 88376000 |Carcinogen (substance), 45986006 |Teratogen (substance)) will be created. Since most substances can exhibit these characteristics in some circumstances, the descendant concepts will not be populated. Exceptions will be noted in the editorial guidelines.

## Exemplar for Grouper Concept Based on Disposition

The following illustrates the **stated** view for grouper concepts based on disposition.

<figure><img src="https://3063935683-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FSZh4aZdgpviXMYp37bCy%2Fuploads%2Fgit-blob-e6162ba8f24618b92a6c8bd64050d11216311d12%2Fimage%20(250).png?alt=media" alt=""><figcaption></figcaption></figure>

The following illustrates the **inferred** view for grouper concepts based on disposition.

<figure><img src="https://3063935683-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FSZh4aZdgpviXMYp37bCy%2Fuploads%2Fgit-blob-052d4d1e558fa6ee07d2c72c3443b6bfa33b8574%2Fimage%20(251).png?alt=media" alt=""><figcaption></figcaption></figure>

<figure><img src="https://github.com/SNOMED-Documents/snomed-editorial-guide/blob/main/authoring/substance/images/174691438.png" alt=""><figcaption></figcaption></figure>

## Terming

### FSN

Use the following pattern for the FSN. The FSN must reflect the terming used to describe the disposition consistent with the terming of the |Has disposition| attribute value.

Example for dispositions that represent a mechanism of action:

* Substance with opioid receptor agonist mechanism of action (substance)
* Substance with histamine receptor antagonist mechanism of action (substance)
* Substance with acetylcholinesterase inhibitor mechanism of action (substance)

***

### Preferred Term

Use the following pattern for the Preferred Term. The Preferred Term must reflect the terming used to describe the disposition consistent with the terming of the |Has disposition| attribute value.

Example for dispositions that represent a mechanism of action:

* Opioid receptor agonist
* Histamine receptor antagonist
* Acetylcholinesterase inhibitor

***

### Synonyms

Synonyms corresponding to the FSN are not required.

Additional synonyms are allowed only if they are consistent with the synonyms for the corresponding disposition concept.

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