# Substance Groupers Based on Structure

<mark style="color:$danger;">**This Editorial Guide is used for Education Purposes Only. It is used in the Authoring Courses and Certifications. It is based on the January 2026 Editorial Guide.**</mark>

## Overview

Groupers based on structural properties of the substance that are deemed to be clinically useful will be included in the Substance hierarchy.

For example,

* Benzodiazepine (substance)
* Quinolone (substance)

## Modeling

<table data-header-hidden><thead><tr><th width="159.15234375">Parent concept</th><th width="677.46875">Most distal appropriate descendant of 312413002 | Substance categorized by structure (substance)|</th></tr></thead><tbody><tr><td><strong>Parent concept</strong></td><td>Most distal appropriate descendant of 312413002 |Substance categorized by structure (substance)|</td></tr><tr><td><strong>Semantic tag</strong></td><td>(substance)</td></tr><tr><td><strong>Definition status</strong></td><td>Primitive</td></tr><tr><td><strong>Attributes</strong></td><td>None</td></tr></tbody></table>

## Exemplar

The following illustrates the **stated** and **inferred** view.

<div align="left"><figure><img src="https://3063935683-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FSZh4aZdgpviXMYp37bCy%2Fuploads%2Fgit-blob-46eb924ad56b3a8d9049b2cade8d064a327a4104%2Fimage%20(244).png?alt=media" alt=""><figcaption></figcaption></figure></div>

<figure><img src="https://github.com/SNOMED-Documents/snomed-editorial-guide/blob/main/authoring/substance/images/174691432.png" alt=""><figcaption></figcaption></figure>

<div align="left"><figure><img src="https://3063935683-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FSZh4aZdgpviXMYp37bCy%2Fuploads%2Fgit-blob-28c2adc9f68a322bd4ccd60f13550647d9008766%2Fimage%20(245).png?alt=media" alt=""><figcaption></figcaption></figure></div>

<figure><img src="https://github.com/SNOMED-Documents/snomed-editorial-guide/blob/main/authoring/substance/images/174691430.png" alt=""><figcaption></figcaption></figure>

<div align="left"><figure><img src="https://3063935683-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FSZh4aZdgpviXMYp37bCy%2Fuploads%2Fgit-blob-e75a1ac5e85d2c93785f4f78a839e8503e0d677e%2Fimage%20(246).png?alt=media" alt=""><figcaption></figcaption></figure></div>

<figure><img src="https://github.com/SNOMED-Documents/snomed-editorial-guide/blob/main/authoring/substance/images/174691429.png" alt=""><figcaption></figcaption></figure>

## Terming

### FSN

Use the following pattern for the FSN. Groupers are expressed in the singular, i.e., *compound* not *compounds*.

Examples of substances that represent a structural grouper:

* Organic nitrogen compound (substance)
* Halide compound (substance)
* Triazine derivative (substance)
* Copper and/or copper compound (substance)
* Phenothiazine and/or phenothiazine derivative (substance)
* Nucleotide (substance)

Where the same word is used to identify both a group of substances with a particular chemical structure and a particular chemical substance, the following terming for the FSN is used for the substance grouper concept.

\
Substance with X structure (substance)

For example,

* Substance with tetracycline structure (substance)
* Substance with cresol structure (substance)
* Substance with benzene structure (substance)

***

### Preferred Term

Use the following pattern for the Preferred Term.

For example,

* Organic nitrogen compound
* Halide compound
* Triazine derivative
* Copper and/or copper compound
* Phenothiazine and/or phenothioazine derivative
* Nucleotide

Where the same word is used to identify both a group of substances with a particular chemical structure and a particular chemical substance the following pattern will be used for PT the substance grouper concept.

Substance with X structure

For example,

* Substance with tetracycline structure
* Substance with cresol structure
* Substance with benzene structure

### Synonyms

Additional synonyms are not allowed unless explicitly identified as an exception in the editorial guidelines.

## Exemplar for Hierarchy

Browser view of 299979007 |Organic nitrogen compound (substance)|

<div align="left"><figure><img src="https://3063935683-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FSZh4aZdgpviXMYp37bCy%2Fuploads%2Fgit-blob-8f2ecd856e3572e3c033160ee205107e437b1802%2Fimage%20(247).png?alt=media" alt=""><figcaption></figcaption></figure></div>

Browser view of 767209009 |Copper and/or copper compound (substance)|

<div align="left"><figure><img src="https://3063935683-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FSZh4aZdgpviXMYp37bCy%2Fuploads%2Fgit-blob-3e08ea5145e958a74708b65af31768adb897897c%2Fimage%20(248).png?alt=media" alt=""><figcaption></figcaption></figure></div>

Browser view of 766224008 |Substance with cresol structure (substance)|

<div align="left"><figure><img src="https://3063935683-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FSZh4aZdgpviXMYp37bCy%2Fuploads%2Fgit-blob-ccd1a2b792de929b815de5907f4728a9fd2c6bb8%2Fimage%20(249).png?alt=media" alt=""><figcaption></figcaption></figure></div>

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