This Editorial Guide is used for Education Purposes Only. It is used in the Authoring Courses and Certifications. It is based on the January 2026 Editorial Guide.
Creation of substance concepts that contain terms such as “free” (or "unbound" or "unconjugated") is limited to the measurement of biological substances (Observable entities, evaluation procedures, LOINC collaboration project) or to report their level (clinical findings). These concepts are created as siblings of the base concepts with a "substance X and X derivatives" or "X and X compound" as common supertype.
Parent concept
Most distal appropriate descendant of 105590001 |Substance (substance)|
Pattern: Free X (substance)
For example,
Free iodine (substance)
Pattern: Free X
For example,
Free iodine
Optional pattern: Unbound x
For example,
Unbound iodine
The following illustrates both the stated and inferred view:
The following illustrates the hierarchy view:
Semantic tag
(substance)
Definition status
Primitive
Attribute
726542003 |Has disposition (attribute)|
