This Editorial Guide is used for Education Purposes Only. It is used in the Authoring Courses and Certifications. It is based on the January 2026 Editorial Guide.

Overview

736479009 |Dose form intended site (intended site)| represents a general type of site of administration (e.g. cutaneous, nasal, oral, parenteral). This subhierarchy is a descendant of 362981000 |Qualifier value (qualifier value)| that supports fully defining the 736542009 |Pharmaceutical dose form (dose form)| hierarchy. |Dose form intended site (intended site)| is used to model concepts in the |Pharmaceutical dose form (dose form)| hierarchy; they are not used to model 763158003 |Medicinal product (product)|.

|Dose form intended site| should not be confused with route of administration , which is a concept used in dosage instructions for the administration of a particular medicinal product to a particular patient.

Modeling

Use the following pattern for the FSN where X is the intended site:

X (intended site)

For example,

• Oral (intended site)

• Otic (intended site)

• Parenteral (intended site)

• Vaginal (intended site)

Use the following pattern for the PT where X is the intended site:

X

For example,

• Oral

• Otic

• Parenteral

• Vaginal

Synonyms are not allowed unless explicitly identified as an exception in the Editorial Guidelines.

Preferred; not required.

This Editorial Guide is used for Education Purposes Only. It is used in the Authoring Courses and Certifications. It is based on the January 2026 Editorial Guide.

The 736542009 |Pharmaceutical dose form (dose form)| subhierarchy of 362981000 |Qualifier value (qualifier value)| contains concepts which support the Medicinal product model.

Editorial guidelines for the supporting hierarchies required to support creation of sufficiently defined pharmaceutical dose form concepts are documented in the following sections.

This Editorial Guide is used for Education Purposes Only. It is used in the Authoring Courses and Certifications. It is based on the January 2026 Editorial Guide.

Overview

736477006 |Dose form transformation (transformation)| represents a process where a dose form is transformed from that supplied by the manufacturer into a new dose form, usually to make it suitable for administration (e.g. dissolving a "powder for solution for injection" dose form into a "solution for injection" dose form). This may occur as part of the dispensing act or immediately before administration.

|Dose form transformation (transformation)| is a descendant of 362981000 |Qualifier value (qualifier value) that supports fully defining the 736542009 |Pharmaceutical dose form (dose form)| hierarchy. |Dose form transformation (transformation)| is used to model the |Pharmaceutical dose form (dose form)| hierarchy; they are not used to model the 763158003 |Medicinal product (product)| hierarchy.

Modeling

Use the following pattern for the FSN where X is the transformation:

• X (transformation)

For example,

• Dissolve (transformation)

• Disperse (transformation)

• No transformation (transformation)

• Disperse or dissolve (transformation)

Use the following pattern for the PT where X is the transformation:

• X

For example,

• Dissolve

• Disperse

• No transformation

• Disperse or dissolve

Synonyms are not allowed unless explicitly identified as an exception in the Editorial Guidelines.

Preferred; not required.

This Editorial Guide is used for Education Purposes Only. It is used in the Authoring Courses and Certifications. It is based on the January 2026 Editorial Guide.

Overview

736480007 |Dose form release characteristic (release characteristic)| represents a general type of pattern of release (e.g. conventional, modified, delayed, prolonged) of the active ingredient substance(s) from the dose form.

|Dose form release characteristic (release characteristic)| is a descendant of 362981000 |Qualifier value (qualifier value) that supports fully defining the 736542009 |Pharmaceutical dose form (dose form)| hierarchy.

|Dose form release characteristic (release characteristic)| is used to model the 736542009 |Pharmaceutical dose form (dose form)| hierarchy; it is not used to model 763158003 |Medicinal product (product)|.

Modeling

Use the following pattern for the FSN where X is the release characteristic, adding a hyphen when appropriate Combined release-characteristic concepts may be created to support modeling of concepts that display multiple release characteristics in a single formulation.

• X (release characteristic)

For example,

• Conventional release (release characteristic)

• Delayed-release (release characteristic)

• Prolonged-release (release characteristic)*

• Modified-release (release characteristic)**

*Prolonged was selected rather than Extended because feedback was received that it is more clear to translate for non-English speaking users; existing national drug extensions appear to use one or the other of these terms.

**Modified-release is a grouper that is not allowed to be used to model an international clinical drug concept.

Use the following pattern for the PT where X is the release characteristic, adding a hyphen when appropriate:

X

For example,

• Conventional release

• Delayed-release

• Prolonged-release

• Modified-release

Synonyms are not allowed unless explicitly identified as an exception in the Editorial Guidelines.

Preferred; not required.

This Editorial Guide is used for Education Purposes Only. It is used in the Authoring Courses and Certifications. It is based on the January 2026 Editorial Guide.

Overview

The dose form administration method represents a general type of method of administration (e.g. apply, chew, spray, swallow) that a dose form is designed to be administered by (e.g. a chewable tablet is formulated to be administered by chewing). To support fully defining concepts in the 736542009 |Pharmaceutical dose form (dose form)| hierarchy, a hierarchy representing dose form administration method is required.

Concepts in the 736665006 |Dose form administration method (administration method)| hierarchy will be used to model concepts in the 736542009 |Pharmaceutical dose form (dose form)| hierarchy; they will not be used to model concepts in the 763158003 |Medicinal product (product)| hierarchy.

The 736665006 |Dose form administration method (administration method)| hierarchy is a descendant of 362981000 |Qualifier value (qualifier value)|.

Modeling

Use the following pattern for the FSN where X is the administration method and is in the form of an imperative:

X (administration method)

For example,

• Administer (administration method)

• Apply (administration method)

• Instill (administration method)

• Spray (administration method)

Use the following pattern for the PT where X is the administration method:

X

For example,

• Administer

• Apply

• Instill

• Spray

Synonyms are not allowed unless explicitly identified as an exception in the Editorial Guidelines.

Preferred; not required.

This Editorial Guide is used for Education Purposes Only. It is used in the Authoring Courses and Certifications. It is based on the January 2026 Editorial Guide.

Overview

736471007 |State of matter (state of matter)| represents a physical state of matter.

|State of matter (state of matter)| is a descendant of 362981000 |Qualifier value (qualifier value) that supports fully defining concepts in the 736542009 |Pharmaceutical dose form (dose form)| hierarchy. |State of matter (state of matter)| is used to model concepts in the 736478001 |Basic dose form (basic dose form)| hierarchy; they are not used to model the 736542009 |Pharmaceutical dose form (dose form)| or 763158003 |Medicinal product (product)| hierarchies.

Modeling

Use the following pattern for the FSN where X is the state of matter:

X (state of matter)

For example,

• Gas (state of matter)

• Liquid (state of matter)

• Semi-solid (state of matter)

• Solid (state of matter)

Use the following pattern for the PT where X is the state of matter:

X

For example,

• Gas

• Liquid

• Semi-solid

• Solid

Synonyms are not allowed unless explicitly identified as an exception in the Editorial Guidelines.

Preferred; not required.

This Editorial Guide is used for Education Purposes Only. It is used in the Authoring Courses and Certifications. It is based on the January 2026 Editorial Guide.

Overview

The basic dose form represents a general type of pharmaceutical formulation (e.g. tablet, capsule, cream, ointment, solution, emulsion) used for medicinal products. To support fully defining concepts in the 736542009 |Pharmaceutical dose form (dose form)| hierarchy, a hierarchy representing basic dose form is required.

Concepts in the 736478001 |Basic dose form (basic dose form)| hierarchy will be used to model concepts in the 736542009 |Pharmaceutical dose form (dose form)| hierarchy; they will not be used to model concepts in the 763158003 |Medicinal product (product)| hierarchy.

The 736478001 |Basic dose form (basic dose form)| hierarchy is a descendant of 362981000 |Qualifier value (qualifier value)|.

Descendants shall be modeled as follows.

Use the following pattern for the FSN; align naming and case sensitivity with the FSN for the concept that is selected as the attribute value, excluding the semantic tag.

• Basic dose form with <State of matter> state of matter (basic dose form)

For example,

• Basic dose form with liquid state of matter (basic dose form)

• Basic dose form with solid state of matter (basic dose form)

Use the following pattern for the PT; align naming and case sensitivity with the PT for the concept that is selected as the attribute value.

• <State of matter PT> state of matter

For example,

• Liquid dose form

• Solid dose form

A synonym to match the FSN is required.

Additional synonyms are not allowed unless explicitly identified as an exception in the Editorial Guidelines.

Preferred; not required.

Use the following pattern for the FSN where X is the basic dose form:

• X (basic dose form)

For example,

• Cream (basic dose form)

• Gel (basic dose form)

• Suppository (basic dose form)

• Tablet (basic dose form)

Exceptions:

• Plural form to be used for Granules (basic dose form)

Use the following pattern for the PT where X is the basic dose form:

• X

For example,

• Cream

• Gel

• Suppository

• Tablet

Exceptions:

• Plural form to be used for Granules

Synonyms are not allowed unless explicitly identified as an exception in the Editorial Guidelines.

Text definitions are not required but are encouraged.