Conjugate acids, bases and salts
Overview
Acids substance concepts should be modeled with a structural parent concept.
Salts should be modeled with a conjugate base as parent (if one exists, otherwise they are modeled with a structural parent). Salts may have an Is modification of (attribute) relationship to the conjugate acid where a specific use case is identified. See examples of such use cases at Concepts Representing a Substance or its Modifications.
Conjugate base concepts (e.g., valproate, pamidronate, etidronate) should only be created where a specific use case is identified, for example, when required to support the definition of other concepts in the terminology.
Conjugate bases should be created as separate concepts - not added as synonyms to the corresponding acid concept.
New instances of substance concepts containing the word salt will not be added. The existing concepts will be reviewed, and if possible, will be replaced by equivalent compounds.
Modeling
Parent concept
Most distal appropriate descendant of 312413002 |Substance categorized structurally (substance)|
Semantic tag
(substance)
Definition status
Primitive
Attribute:
Is Modification of
Range <105590001 |Substance (substance)|
Cardinality: 0..1
Used to identify the conjugate acid
Attribute:
Has disposition
Range: <726711005 |Disposition (disposition)|
While the allowed range is broader, substance concepts should only use <726711005 |Disposition (disposition)| as the attribute value.
Cardinality: 0..1
Naming
Where INN names exist, these should be used for the FSN and PT.
FSN
Pattern:
X sulfate (substance)
X pamidronate (substance)
For example,
Copper sulfate (substance)
Disodium pamidronate (substance)
Etidronate (substance)
Exception:
Valproate sodium (substance)
Preferred Term
Pattern:
X sulfate
X pamidronate
For example,
Copper sulfate
Pamidronate monosodium
Etidronate
Exception:
Valproate sodium
Synonyms
Pattern: Pamidronate X
For example,
Pamidronate monosodium
Valproate sodium
Exemplar
Stated view of 387080000 |Valproic acid (substance)|:
Stated and inferred view of 387481005 |Sodium valproate (substance)|:
Hierarchy view of 264325000 |Valproate (substance)| subtypes:
The following illustrates the stated and inferred views.
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