> For the complete documentation index, see [llms.txt](https://docs.snomed.org/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://docs.snomed.org/snomed-ct-specifications/snomed-ct-editorial-guide/readme/authoring/domain-specific-modeling/substance/substance-naming-and-modeling-conventions/guidelines-for-substance-hierarchy-grouper-concepts/substance-groupers-based-on-disposition.md).

# Substance Groupers Based on Disposition

## Overview

Groupers based on disposition that are deemed to be clinically useful and that can be sufficiently defined will be included in the |Substance| hierarchy. Disposition is defined as a behavior that a substance will exhibit or participate in, given the appropriate context. There is no requirement to introduce a new semantic tag in order to distinguish concepts representing a substance disposition from any other type of concept in the |Substance| hierarchy.

*Note: This section applies to concepts representing a single disposition. It does not apply to concepts representing a disposition combined with a structural grouper or concepts representing more than one disposition.*

See also:

* [Substance; Supporting hierarchy - Disposition](https://docs.snomed.org/snomed-ct-specifications/snomed-ct-editorial-guide/readme/authoring/domain-specific-modeling/substance/supporting-hierarchy-disposition)
* [Substance Groupers Based on Disposition](https://docs.snomed.org/snomed-ct-specifications/snomed-ct-editorial-guide/readme/authoring/domain-specific-modeling/substance/substance-naming-and-modeling-conventions/guidelines-for-substance-hierarchy-grouper-concepts/substance-groupers-based-on-disposition)

## Modeling

<table data-header-hidden><thead><tr><th width="176.88671875">Parent concept</th><th>105590001 |Substance (substance)|</th></tr></thead><tbody><tr><td><strong>Parent concept</strong></td><td>105590001 |Substance (substance)|</td></tr><tr><td><strong>Definition status</strong></td><td>Defined</td></tr><tr><td><strong>|Has disposition|</strong></td><td><p>Range: &#x3C;726711005 |Disposition (disposition)</p><ul><li>While the allowed range is broader, the Substance Groupers based on Disposition should only use &#x3C;726711005 |Disposition (disposition) as the attribute value.</li></ul><p>Cardinality: 1..1</p><ul><li>While the allowed range is broader, the Substance Groupers based on Disposition should have one and only one |Has disposition| attribute.</li></ul></td></tr></tbody></table>

Substance groupers representing etiopathic dispositions (e.g. 88376000 |Carcinogen (substance), 45986006 |Teratogen (substance)) will be created. Since most substances can exhibit these characteristics in some circumstances, the descendant concepts will not be populated. Exceptions will be noted in the editorial guidelines.

## Exemplar for Grouper Concept Based on Disposition

The following illustrates the **stated** view for grouper concepts based on disposition.

<figure><img src="https://4060284305-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FuoSxuN6wQMDYcvuq2wNX%2Fuploads%2Fl0u77kf6z9DvzRT1bGYh%2Fimage.png?alt=media&amp;token=64bdf442-eef5-4d16-9ba8-92988267fb29" alt=""><figcaption></figcaption></figure>

The following illustrates the **inferred** view for grouper concepts based on disposition.

<figure><img src="https://4060284305-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FuoSxuN6wQMDYcvuq2wNX%2Fuploads%2FE9nvNvBmKa36kc0TxFFu%2Fimage.png?alt=media&amp;token=fb1c4c88-cb41-444b-bc22-fbb0a83a73ad" alt=""><figcaption></figcaption></figure>

<figure><img src="https://github.com/SNOMED-Documents/snomed-editorial-guide/blob/main/authoring/substance/images/174691438.png" alt=""><figcaption></figcaption></figure>

## Terming

### FSN

Use the following pattern for the FSN. The FSN must reflect the terming used to describe the disposition consistent with the terming of the |Has disposition| attribute value.

Example for dispositions that represent a mechanism of action:

* Substance with opioid receptor agonist mechanism of action (substance)
* Substance with histamine receptor antagonist mechanism of action (substance)
* Substance with acetylcholinesterase inhibitor mechanism of action (substance)

***

### Preferred Term

Use the following pattern for the Preferred Term. The Preferred Term must reflect the terming used to describe the disposition consistent with the terming of the |Has disposition| attribute value.

Example for dispositions that represent a mechanism of action:

* Opioid receptor agonist
* Histamine receptor antagonist
* Acetylcholinesterase inhibitor

***

### Synonyms

Synonyms corresponding to the FSN are not required.

Additional synonyms are allowed only if they are consistent with the synonyms for the corresponding disposition concept.

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