Continuous presentation: Metered dose unit of presentation
Examples: various inhalers, nasal sprays, some cutaneous sprays/foams
The unit of presentation is the actuation, the “single operation of a metered-dose pump, valve or other equivalent dosing mechanism” [EDQM].
Strength is expressed as “per one unit of presentation” and the presentation strength and the concentration are exactly the same.
Example: Single inhaler containing a total of 200 actuations worth of salbutamol, 100 micrograms per actuation, packaged in a box
Manufactured dose form
Solution for aerosolisation
Unit of presentation
Actuation
[Pack size]
200 actuations in the inhaler
Precise active ingredient
salbutamol sulphate
Basis of strength substance
salbutamol
Presentation strength (logical)
100 mcg per 1 unit of presentation
Presentation strength
100 mcg per 1 actuation
UCUM: 100 mcg per 1 each
Concentration strength
The concentration of salbutamol sulphate in the inhalant solution inside the inhaler container is probably known to the regulatory agency but is not deemed clinically significant.
