Substance Groupers Based on Both Structure and Disposition

Overview

Groupers based on both structure and disposition that are deemed to be clinically useful and that can be sufficiently defined will be included in the |Substance| hierarchy.

Note: This section applies to concepts representing a single structural parent and a single disposition. It does not apply concepts representing more than one structural parent or disposition.

Modeling

The following illustrates the stated and inferred view for grouper concepts based on both structure and disposition.

Use the following pattern for the FSN, with X representing the structure and Y representing the disposition. The FSN should align with the FSN for the substance grouper and disposition used as the stated parent and attribute value respectively.

• X with Y mechanism of action (substance)

For example,

• Piperazine derivative with histamine H1 receptor antagonist mechanism of action (substance)

• Substance with dihydropyridine derivative structure and calcium channel blocker mechanism of action (substance)

• Substance with organophosphorus structure and acetylcholinesterase inhibitor mechanism of action (substance)

Use the following pattern for the Preferred Term, with X representing the structure and Y representing the disposition. The FSN should align with the FSN for the substance grouper and disposition used as the stated parent and attribute value respectively.

• X Y

For example,

• Piperazine derivative histamine H1 receptor antagonist

• Dihydropyridine derivative calcium channel blocker

• Organophosphorus acetylcholinesterase inhibitor

A synonym to match the FSN is not required.

Additional synonyms are allowed only if they are consistent with the synonyms for the corresponding structure grouper and disposition.