Generally, SNOMED CT descriptions begin with an upper case letter; the rest of the words in the description are lower case, except for abbreviations and proper nouns (names of people, organizations, taxonomic groups (e.g. species, genus, family)).
cI
900000000000020002 | Only initial character case insensitive (core metadata concept)|
Special attention is to be paid to the possibility of altering the semantics of those concepts whose FSN uniqueness depends upon case significance.
For example,
The subtypes of 365638007 |Finding of Rh blood group (finding)| vary in meaning depending upon the description's case of the letters c, d, and e.
SNOMED CT includes three case significance values: ci, cI, and CS. However, this range of values depends on the languages and linguistic norms. For the International Edition, where the first character of descriptions is always capitalized, the value Only initial character case insensitive (cI) is necessary. This value is not required for descriptions in extensions that do not adhere to this convention. When appropriate, it is also acceptable to limit the range to a single case significance value.
Non-taxonomic groupers, such as “Human herpes simplex virus”, are recorded with a case sensitivity indicator of Entire term case insensitive (ci).
There are cases where the authoritative resources do not have an entry for the official name of an organism. For these concepts, the associated literature is referenced for naming and case sensitivity assignments.
For example,
“Severe acute respiratory syndrome coronavirus 2” is below species level and does not have an entry in the authoritative resource, International Committee on Taxonomy of Viruses (ICTV). Therefore, it is recorded with a case sensitivity indicator of Entire term case insensitive (ci), since the majority of references do not capitalize “severe”.
When an organism is part of the term of a concept in another hierarchy, it is capitalized. However, when the general reference to the organism is part of the term, the term in the description is not capitalized.
For example,
19431000 |Infective arthritis caused by Rubella virus (disorder)| - Since the Rubella virus is specified, Rubella is capitalized.
1857005 |Congenital rubella syndrome (disorder)| - Since rubella refers to the disease, rubella is not capitalized.
When the species Vaccinia virus (of the genus Orthopoxvirus) is specified, Vaccinia is capitalized.
For example,
293120003 |Adverse reaction to component of vaccine product containing Vaccinia virus antigen (disorder)|
When vaccinia is describing a condition, vaccinia is not capitalized.
For example,
56978007 |Generalized vaccinia (disorder)|
Numeric values will not display differently if switched between upper and lower case, so numeric values should be treated as case insensitive characters in a term.
If a description begins with a numeric value and the word following the number does not begin with a capital letter, the case sensitivity indicator is ci for Entire term case insensitive.
For example,
The concept 33635003 | Serotonin (substance)| has the synonym, 5-hydroxytryptamine. The description is recorded in SNOMED CT in lower case, not 5-Hydroxytryptamine, but the case sensitivity indicator is ci for Entire term case insensitive.
If a description begins with a numeric value and follows with an abbreviation that contains a capital letter, the case sensitivity indicator is cl for Initial character case insensitive.
For example,
The concept 387407006 | Tioguanine (substance)| has the synonym, 6-TG. Apply the case sensitivity indicator of cl for Only initial character case insensitive.
The case significance setting for concepts that represent formal gene names are to align with the source (usually HGNC). However, when referring to the disease caused by the gene, there is no such requirement, and the standard terming editorial guidance applies. The disorder caused by the gene should have an initial capital letter, even if the name of the disease is the same as the gene name. Exceptions are if the initial letter of the disorder is case sensitive; for example, 48449016 |tRNA|, 1402127002 |APC regulator of Wnt signaling pathway 2 gene related Sotos syndrome (disorder)|.
Special characters such as <, %, >, . , &, ^, will not display differently if switched between upper and lower case, so numeric values should be treated as case insensitive characters in a term. The rules for numeric values apply similarly to special characters.
If a description begins with a special character and the word(s) and/or symbol(s) following the special character begins with a capital letter, the case sensitivity indicator is cl for Initial character case insensitive.
For example,
The concept
277976001 | Less than 35 degrees C (qualifier value)| has the synonym, <35 degrees C. The description starts with a special character that is case insensitive but contains an abbreviation "C" for Celsius that is case sensitive, so the case sensitivity indicator applied to the synonym is cl for Only initial character case insensitive.
SNOMED CT descriptions representing assessment scales and staging systems should be capitalized per the name of the scale or staging system. Legacy concepts may not follow this pattern.
For example,
Ages and Stages Questionnaires Third Edition (assessment scale)
Fagerstrom test for nicotine dependence (assessment scale)
National Cancer Institute histologic grading system (staging scale)
Clark system for melanoma staging (staging scale)
First character of the description may or may not be capitalized while the case of the rest of the description cannot be changed
Family history of Prader-Willi syndrome (situation)
Born in Australia (finding)
Neonatal jaundice with Dubin-Johnson syndrome (disorder)
Penicillin resistant Streptococcus pneumoniae (organism)
CS
900000000000017005 | Entire term case sensitive (core metadata concept)|
Cannot change any case in the description
Changing case may change the meaning of the term or is not commonly used
Down syndrome (disorder)
English as a second language (finding)
pH measurement (procedure)
mm (qualifier value)
ci
900000000000448009 | Entire term case insensitive (core metadata concept)|
Entire description may be lower or upper case
Changing case does not change the meaning of the term
Fracture of tibia (disorder)
Blood compatibility test (procedure)
Bite of fish (event)
Floor mat (physical object)
Gravida (observable entity)
Case sensitivity can be changed on an existing description without inactivating the description.
The common name for |Structure of pharyngotympanic tube (body structure)| is eustachian tube. While the term originated eponymously, it is not the name of the person from whom the body structure was named after. Therefore, the case significance is ci for case insensitive.
For more information, see Organism Naming Conventions.
Greek alphabet characters Words derived from the Greek alphabet, for example, alpha, beta, delta, gamma, omega, etc., are case insensitive wherever they are in the description in the substance hierarchy.
Gram staining Gram staining is a common laboratory technique used to differentiate bacteria based on their cell wall constituents. Laboratory test results may be Gram positive or Gram negative. The technique was developed by a Danish physician, Hans Christian Gram. Consequently Gram, when referring to the technique, should always begin with an upper case G.