# Simple Expression Constraints - Invalid

{% hint style="info" %}
1 Where necessary, these examples make some assumptions about the membership of the example reference sets.\
2 Please note that this makes the assumption that the given expression constraint is executed against a finite set of expressions that has been pre-classified (e.g. in an expression repository), and that after classification there is at least one intermediate expression between this expression and 404684003 |Clinical finding|.\
3 Please note that this makes the assumption that the given expression constraint is executed against a finite set of expressions that has been pre-classified (e.g. in an expression repository), and that after classification there is at least one intermediate expression between 40541001 |Acute pulmonary edema| and this expression.
{% endhint %}

<table data-full-width="true"><thead><tr><th width="279.265625">Invalid Expression Constraint</th><th width="290.84375">Precoordinated</th><th>Postcoordinated</th></tr></thead><tbody><tr><td>404684003 | Clinical finding|</td><td>56265001 | Heart disease| 71388002 | Procedure|</td><td>404684003 | Clinical finding| : 363698007 | Finding site| = 80891009 | Heart structure|</td></tr><tr><td>&#x3C; 404684003 | Clinical finding|</td><td>404684003 | Clinical finding| 71388002 | Procedure|</td><td>71388002 | Procedure| : 405813007 | Procedure site - Direct| = 80891009 | Heart structure|</td></tr><tr><td>&#x3C;&#x3C; 73211009 | Diabetes mellitus|</td><td>71388002 | Procedure|</td><td>404684003 | Clinical finding| : 363698007 | Finding site| = 113331007 | Structure of endocrine system| 362969004 | Disorder of endocrine system|</td></tr><tr><td>&#x3C;! 404684003 | Clinical finding|</td><td>404684003 | Clinical finding| 233709006 | Toxic pulmonary edema|</td><td>404684003 | Clinical finding| : 116676008 | Associated morphology| = 79654002 | Edema| , 363698007 | Finding site| = 80891009 | Heart structure| > 40541001 | Acute pulmonary edema|</td></tr><tr><td>> 40541001 | Acute pulmonary edema|</td><td>40541001 | Acute pulmonary edema| 233709006 | Toxic pulmonary edema|</td><td>40541001 | Acute pulmonary edema| : 246112005 | Severity| = 24484000 | Severe| 304527002 | Acute asthma|</td></tr><tr><td>>> 40541001 | Acute pulmonary edema|</td><td>233709006 | Toxic pulmonary edema|</td><td>40541001 | Acute pulmonary edema| : 246112005 | Severity| = 24484000 | Severe| 304527002 | Acute asthma|</td></tr><tr><td>>! 40541001 | Acute pulmonary edema|</td><td>404684003 | Clinical finding| 267038008 | Edema|</td><td>64572001 | Disease| : 263502005 | Clinical course| = 424124008 | Sudden onset AND/OR short duration|</td></tr><tr><td>^ 700043003 | Example problem list concepts reference set|</td><td>6143009 | Diabetic education| 75367002 | Blood pressure|</td><td>71388002 | Procedure| : 405813007 | Procedure site - Direct| = 80891009 | Heart structure|</td></tr><tr><td>*</td><td>–</td><td>–</td></tr></tbody></table>

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