# Nested Expression Constraints - Invalid

<table data-full-width="true"><thead><tr><th>Inalid Expression Constraint</th><th>Precoordinated</th><th>Postcoordinated</th></tr></thead><tbody><tr><td>&#x3C;&#x3C; (^ 700043003 | Example problem list concepts reference set| )</td><td>6143009 | Diabetic education| 75367002 | Blood pressure|</td><td>71388002 | Procedure| : 405813007 | Procedure site - Direct| = 80891009 | Heart structure|</td></tr><tr><td>^ (&#x3C; 450973005 | GP/FP health issue reference set| )</td><td>80146002 | Appendectomy| 305342007 | Admission to ward|</td><td>–</td></tr><tr><td>(&#x3C; 404684003 | Clinical finding| : 363698007 | Finding site| = &#x3C;&#x3C; 39057004 | Pulmonary valve structure| ) AND ^ 700043003 | Example problem list concepts reference set|</td><td>125605004 | Fracture of bone| 195967001 | Asthma|</td><td>404684003 | Clinical finding| : 363698007 | Finding site| = 17401000 | Cardiac valve structure|</td></tr><tr><td>(&#x3C; 404684003 | Clinical finding| : 363698007 | Finding site| = &#x3C;&#x3C; 39057004 | Pulmonary valve structure| ) AND (&#x3C; 64572001 | Disease| : 116676008 | Associated morphology| = &#x3C;&#x3C; 415582006 | Stenosis| )</td><td>301104003 | Pulmonary valve finding| 76107001 | Spinal stenosis|</td><td>404684003 | Clinical finding| : 363698007 | Finding site| = 39057004 | Pulmonary valve structure| 64572001 | Disease| : 116676008 | Associated morphology| = 415582006 | Stenosis|</td></tr><tr><td>(&#x3C;&#x3C; 17636008 | Specimen collection| : 424226004 | Using device| = &#x3C;&#x3C; 19923001 | Catheter| ) . 363701004 | Direct substance|</td><td>57617002 | Urine specimen collection| 122575003 | Urine specimen|</td><td>17636008 | Specimen collection| : 424226004 | Using device| = 19923001 | Catheter|</td></tr><tr><td>(&#x3C;&#x3C; 404684003 | Clinical finding (finding)| OR &#x3C;&#x3C; 272379006 | Event (event)| ) : 255234002 | After| = &#x3C;&#x3C; 71388002 | Procedure (procedure)|</td><td>293690005 | Peppermint oil allergy| 82510005 | Posttraumatic vertigo|</td><td>404684003 | Clinical finding| : 255234002 | After| = 417163006 | Injury|</td></tr><tr><td>&#x3C;&#x3C; 125605004 | Fracture of bone| : [0..0] ((&#x3C;&#x3C; 410662002 | Concept model attribute| MINUS 363698007 | Finding site| ) MINUS 116676008 | Associated morphology| ) = *</td><td>704333004 | Pathological fracture of hand due to osteoporosis| 722571004 | Linear fracture of skull due to birth trauma|</td><td>125605004 | Fracture of bone| : 42752001 | Due to| = 417163006 | Injury|</td></tr><tr><td>&#x3C; 404684003 | Clinical finding| : 47429007 | Associated with| = (&#x3C; 404684003 | Clinical finding| : 116676008 | Associated morphology| = &#x3C;&#x3C; 55641003 | Infarct| )</td><td>3238004 | Pericarditis|</td><td>64572001 | Disease| : 47429007 | Associated with| = (404684003 | Clinical finding| : 363698007 | Finding site| = 277712000 | Cardiac internal structure| )</td></tr></tbody></table>

{% hint style="info" %}
Where necessary, these examples make some assumptions about the membership of the example reference sets.
{% endhint %}

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