Medicinal Product and Medicinal Product Forms
When a clinical drug is created, the following supertypes must either already exist or must be created:
Medicinal Product containing onlyMedicinal Product containingMedicinal Product Form (MPF)For example,
1172863005 Paracetamol 1 g oral tablet has the following supertypes:
These concepts in the International Release, their descriptions, and their| Has active ingredient (attribute)|value, represent the base ingredient, not a modification.
For example,
1204319004 |Product containing precisely retinol (as retinol palmitate) 50000 unit/1 milliliter conventional release solution for injection (clinical drug)| has medicinal product and medicinal product form supertypes with retinol , not retinol palmitate. Retinol palmitate is a modification of Retinol and thus should not be used in the creation of the medicinal product and medicinal product form supertypes.
Exceptions to use a modified substance are explicitly identified below:
Benzylpenicillin
When the active ingredient has an Is modification of (attribute) value of 323389000 |Benzylpenicillin (substance)|.
1234765004
Chemical element compound with multiple modification
Instances where the chemical element compound has two or more Is Modification of (attribute)s
422232005
Chloral hydrate
273948005 |Chloral hydrate (substance)| is a modification of Chloral. However, chloral is unstable on its own and always exists in the hydrated form.
778711000
Liposome or lipid complex substances
< 414612001
Liposomal agent (substance)
These subtypes have some sort of modification, but they can be used to create:
Product containing only x (medicinal product)
Product containing only x in y dose form (medicinal product form)
Do not use to create:
Product containing x (medicinal product)
Product containing x in y dose form (medicinal product form)
Pegylated substance
There is no technical way to identify these concepts, though they will often begin with peg-.
385544005
Radiopharmaceutical
< 89457008 Radioactive isotope (substance)|
783865003
Silver sulfadiazine
387112002 |Silver sulfadiazine (substance)| is a modification of 74523009 |Sulfadiazine (substance)|.
864009007
Sodium valproate
387481005 |Sodium valproate (substance)| is a modification of 387080000 |Valproic acid (substance)|.
766519009
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